Intravenous versus intramyometrial injection of carbetocin for reduction of blood loss during myomectomy operation

Background: Leiomyomas cause significant morbidity due to abnormal uterine bleeding and pelvic pressure symptoms. Carbetocin is a long-acting synthetic agonist analogue of the human oxytocin which induces contractions. The study aims compare intravenous carbetocin clinical effect its myometrial injection decrease blood loss in myomectomy operation. Methods: This randomized controlled involved 60 patients who clinically sonographically diagnosed with single intramural fibroids. Patients were allocated into three equal groups: Group A (Intravenous cabetocin group), group B (Myometrial group) C (Control group). All underwent abdominal ultra-sonography, routine laboratory investigation. Results: was more in-group than high difference between groups (P<0.001). Preoperatively there Hb (0.002), but postoperatively insignificant both groups. Conclusions: use during preoperative operation effective decreasing loss, shorter operative time, transfusion rapid postoperative recovery intramyometrial injection.